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Article

Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers.

Molecular pathology : MP - 1 Aug 2001

Vaziri S A, Tubbs R R, Darlington G, Casey G

Abstract excerpt

BACKGROUND/AIMS: It was recently reported that significantly fewer breast tumours of BRCA1 mutation carriers overexpressed cyclin D1 and HER2 protein than tumours of age matched breast cancer cases unselected for family history. This study aimed to examine the genetic basis of this reduction by d...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Genes, BRCA1

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Share to In Situ Hybridization, Fluorescence

Source

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Identifiers

PMID: 11477142
DOI: 10.1136/mp.54.4.259
PMCID: PMC1187078

Genes

BRCA1
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11477142-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers.PMID 11477142Read ↗

Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysisSemantic proximity Read ↗

Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer.Semantic proximity Read ↗

Familial breast cancers without mutations in BRCA1 or BRCA2 have low cyclin E and high cyclin D1 in contrast to cancers in BRCA mutation carriers.Semantic proximity Read ↗

Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assaysSemantic proximity Read ↗

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.Semantic proximity Read ↗

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.Semantic proximity Read ↗

Cyclin D1 protein expression and function in human breast cancerSemantic proximity Read ↗

CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer.Semantic proximity Read ↗

Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers.Semantic proximity Read ↗

Non-existence of caveolin-1 gene mutations in human breast cancer.Semantic proximity Read ↗

Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancerSemantic proximity Read ↗

Breast tumor immunophenotype of BRCA1-mutation carriers is influenced by age at diagnosis.Semantic proximity Read ↗

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