Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.

doi:10.1038/bjc.1998.240

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Article

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.

British journal of cancer - 1 May 1998

Marsh K L, Varley J M

Abstract excerpt

Progression through G1 phase of the eukaryotic cell cycle is tightly controlled by cyclin-dependent kinases (CDK). These proteins form part of a regulatory pathway including the cyclin-dependent kinase inhibitor (CKI) p16, D-type cyclins and the product of the retinoblastoma gene pRb. Aberration...

Topics

Alleles
Breast Neoplasms
Carcinoma, Ductal, Breast
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Female
Humans
Immunohistochemistry
Neoplasm Proteins
Retinoblastoma Protein

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