Article
Familial breast cancers without mutations in BRCA1 or BRCA2 have low cyclin E and high cyclin D1 in contrast to cancers in BRCA mutation carriers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2008
Aaltonen Kirsimari, Blomqvist Carl, Amini Rose-Marie, Eerola Hannaleena, Aittomäki Kristiina, Heikkilä Päivi, Nevanlinna Heli
Abstract excerpt
PURPOSE: We analyzed the expression of critical cell cycle regulators cyclin E and cyclin D1 in familial breast cancer, focusing on BRCA mutation-negative tumors. Cyclin E expression in tumors of BRCA1 or BRCA2 carriers is higher, and cyclin D1 expression lower, than in sporadic tumors. In familial non-BRCA1/2 tumors, cyclin E and cyclin D1 expression has not been studied. EXPERIMENTAL DESIGN: Cyclin E and cyclin...
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