Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm.

Developmental biology - 15 Aug 2001

Goswami M, Uzgare A R, Sater A K

Abstract excerpt

Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 receptor resulted in a 4.5-fold elevation in MAPK activity in midgastrula ectoderm. MAPK activity was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Ectoderm
Share to Gastrula

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

Share to MAP Kinase Kinase Kinases

Share to Neural Cell Adhesion Molecules

Share to Otx Transcription Factors

Share to Receptors, Growth Factor

Source

Identifiers

PMID: 11476570
DOI: 10.1006/dbio.2001.0338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm.PMID 11476570Read ↗

Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.Semantic proximity Read ↗

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.Semantic proximity Read ↗

Mice with Tak1 Deficiency in Neural Crest Lineage Exhibit Cleft Palate Associated with Abnormal Tongue DevelopmentSemantic proximity Read ↗

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube developmentSemantic proximity Read ↗

BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureterSemantic proximity Read ↗

The role of the Drosophila TAK homologue dTAK during development.Semantic proximity Read ↗

p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis.Semantic proximity Read ↗

Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.Semantic proximity Read ↗

TAK1 mediates BMP signaling in cartilageSemantic proximity Read ↗

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.Semantic proximity Read ↗

MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells.Semantic proximity Read ↗

Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.