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Article

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.

Genesis (New York, N.Y. : 2000) - 1 Mar 2018

Liu Xia, Hayano Satoru, Pan Haichun, Inagaki Maiko, Ninomiya-Tsuji Jun, Sun Hongchen, Mishina Yuji

Abstract excerpt

BMP signaling plays a critical role in craniofacial development. Augmentation of BMPR1A signaling through neural crest-specific expression of constitutively active Bmpr1a (caBmpr1a) results in craniofacial deformities in mice. To investigate whether deletion of Tak1 may rescue the craniofacial deformities caused by enhanced Smad-dependent signaling through caBMPR1A, we generated embryos to activate transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29411501
DOI: 10.1002/dvg.23093
PMCID: PMC5854540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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