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Article

Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.

Developmental cell - 1 Aug 2008

Xu Xun, Han Jun, Ito Yoshihiro, Bringas Pablo, Deng Chuxia, Chai Yang

Abstract excerpt

Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palate development and noted that conditional inactivation of Smad4 in oral epithelium results in much...

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Identifiers

PMID: 18694570
DOI: 10.1016/j.devcel.2008.06.004
PMCID: PMC2610417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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