Article
Growth hormone and insulin-like growth factor-I: effects on the growth of glioma cell lines.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Apr 2001
Friend K E, Khandwala H M, Flyvbjerg A, Hill H, Li J, McCutcheon I E
Abstract excerpt
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are known to be mitogens for many types of neoplasms. To investigate their role in tumors of glial origin, in vitro and in vivo experiments were performed with a panel of immortalized glioma cell lines (D54, SNB-19, U87, U251 and U373). Initial analysis for mRNA expression demonstrated the following: GH receptor (5/5 cell lines positive), IGF-I (0/5),...
Topics
- Animals
- Cell Division
- Central Nervous System Neoplasms
- DNA
- Female
- Gene Expression Regulation, Neoplastic
- Glioma
- Growth Hormone
- Humans
- Insulin-Like Growth Factor Binding Protein 3