Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells.

doi:10.1002/jnr.490340503

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Article

Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells.

Journal of neuroscience research - 1 Apr 1993

Morrison R S, Giordano S, Yamaguchi F, Hendrickson S, Berger M S, Palczewski K

Abstract excerpt

Basic fibroblast growth factor (bFGF) is a heparin-binding protein, expressing potent mitogenic and angiogenic properties. Elevated levels of bFGF have been identified in human gliomas and glioma cell lines, suggesting that bFGF expression is involved in the aberrant growth patterns associated with these tumors. In the present study, the influence of bFGF on additional parameters of glioma cell malignancy was...

Topics

Astrocytes
Base Sequence
Brain Neoplasms
Cell Division
Fibroblast Growth Factor 2
Glioma
Humans
Molecular Sequence Data
Oligonucleotides, Antisense
Phenotype
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8478985
DOI: 10.1002/jnr.490340503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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