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Article

Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.

Cardiovascular research - 1 Aug 2001

Junker R, Kotthoff S, Vielhaber H, Halimeh S, Kosch A, Koch H G, Kassenböhmer R, Heineking B, Nowak-Göttl U

Abstract excerpt

OBJECTIVE: Recently, an association between the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in infants with congenital neural tube defects or congenital oral clefts has been shown. However, no data are available so far with respect to the MTHFR 677TT genotype in children with underlying structural congenital heart disease (CHD). METHODS: We investigated the MTHFR genotype in...

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Source

Identifiers

PMID: 11470464
DOI: 10.1016/s0008-6363(01)00286-3

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.PMID 11470464Read ↗

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Association between MTHFR C677T polymorphism and congenital heart disease. A family-based meta-analysis.Semantic proximity Read ↗

Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.Semantic proximity Read ↗

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