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Article

Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein.

Oncogene - 19 Jul 2001

Keating K E, Gueven N, Watters D, Rodemann H P, Lavin M F

Abstract excerpt

There is evidence that ATM plays a wider role in intracellular signalling in addition to DNA damage recognition and cell cycle control. In this report we show that activation of the EGF receptor is defective in ataxia-telangiectasia (A-T) cells and that sustained stimulation of cells with EGF downregulates ATM protein in control cells but not in A-T cells expressing mutant protein. Concomitant with the...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to DNA, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epidermal Growth Factor

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Source

Identifiers

PMID: 11466608
DOI: 10.1038/sj.onc.1204527

Genes

ATM
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein.PMID 11466608Read ↗

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