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Article

Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2016

Neal Jessica A, Xu Yao, Abe Masumi, Hendrickson Eric, Meek Katheryn

Abstract excerpt

Unlike most DNA-dependent protein kinase, catalytic subunit (DNA-PKcs)-deficient mouse cell strains, we show in the present study that targeted deletion of DNA-PKcs in two different human cell lines abrogates VDJ signal end joining in episomal assays. Although the mechanism is not well defined, DNA-PKcs deficiency results in spontaneous reduction of ATM expression in many cultured cell lines (including those...

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Source

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Identifiers

PMID: 26921311
DOI: 10.4049/jimmunol.1501654
PMCID: PMC4799769

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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