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Article

ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response

6 Feb 2001

Abstract excerpt

The ATM gene is mutated in the syndrome of ataxia telangiectasia (AT), associated with neurologic dysfunction, growth abnormalities, and extreme radiosensitivity. Insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor with tyrosine kinase activity that can mediate mitogenesis, cell transformation, and inhibition of apoptosis. We report here that AT cells express low levels of IGF-IR and show...

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Identifiers

PMID: 11172010
DOI: 10.1073/pnas.98.4.1676

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