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Article

Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway.

European journal of immunology - 1 May 2001

van Seventer G A, Salmen H J, Law S F, O'Neill G M, Mullen M M, Franz A M, Kanner S B, Golemis E A, van Seventer J M

Abstract excerpt

Although beta1 integrin-dependent T cell migration is required for immune function, little is known of the signaling pathways regulating this migration. We now show that the cytoplasmic tyrosine kinase, focal adhesion kinase (FAK) plays an essential role in the beta1 integrin-stimulated migration of T cells through regulation of the unique Crk-associated substrate (Cas) family docking protein, human enhancer of...

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Source

Identifiers

PMID: 11465098
DOI: 10.1002/1521-4141(200105)31:5<1417::AID-IMMU1417>3.0.CO;2-C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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