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Article

The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.

Molecular and cellular biology - 1 Jul 2000

Law S F, O'Neill G M, Fashena S J, Einarson M B, Golemis E A

Abstract excerpt

HEF1 (human enhancer of filamentation 1) is a member of a docking protein family that includes p130(Cas) and Efs. Through assembly of multiple protein interactions at focal adhesion sites, these proteins activate signaling cascades in response to integrin receptor binding of the extracellular matrix. The HEF1 protein is cell cycle regulated, with full-length forms cleaved in mitosis at a caspase consensus site to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10866674
DOI: 10.1128/MCB.20.14.5184-5195.2000
PMCID: PMC85967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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