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Article

Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

International journal of oncology - 1 Jun 2013

Haneji Tatsuji, Hirashima Kanji, Teramachi Jumpei, Morimoto Hiroyuki

Abstract excerpt

Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and phosphorylation of IκBα, as judged from the results of real-time PCR and western blot analysis. We...

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Identifiers

PMID: 23591640
DOI: 10.3892/ijo.2013.1911
PMCID: PMC3699595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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