Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T ‐cell receptor CD 3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

23 Nov 2015

Abstract excerpt

Decreased expression of CD3-ζ chain, an adaptor protein associated with T-cell signalling, is well documented in patients with oral cancer, but the mechanistic justifications are fragmentary. Previous studies in patients with oral cancer have shown that decreased expression of CD3-ζ chain was associated with decreased responsiveness of T cells. Tumours are known to induce localized as well as systemic immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26595239
DOI: 10.1111/imm.12560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T ‐cell receptor CD 3‐ζ chain down‐regulation via caspase‐3 activation in oral cancerPMID 26595239Read ↗

The large form of human 2′,5′-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virusSemantic proximity Read ↗

Establishment of okadaic acid resistant cell clones using a cDNA expression library.Semantic proximity Read ↗

Alternative Splicing Factor/Splicing Factor 2 Regulates the Expression of the ζ Subunit of the Human T Cell Receptor-associated CD3 ComplexSemantic proximity Read ↗

Pan-cancer multi-omics profiling of OAS3 reveals its immunological and prognostic associations across human cancers.Semantic proximity Read ↗

Downregulation of SLC3A2 mediates immune evasion and accelerates metastasis in oral squamous cell carcinomaSemantic proximity Read ↗

A Pan-Cancer Analysis Reveals OAS2 as a Biomarker for Cancer Prognosis and ImmunotherapySemantic proximity Read ↗

The Role of YY1 in the Regulation of LAG-3 Expression in CD8 T Cells and Immune Evasion in Cancer: Therapeutic ImplicationsSemantic proximity Read ↗

Multi-omics landscape of Interferon-stimulated gene OASL reveals a potential biomarker in pan-cancer: from prognosis to tumor microenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.