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Article

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2.

Cell death and differentiation - 1 Jul 2001

Schimmer A D, Hedley D W, Chow S, Pham N A, Chakrabartty A, Bouchard D, Mak T W, Trus M R, Minden M D

Abstract excerpt

Since the over-expression of Bcl-2 is a common cause of multi-drug resistance, cytotoxic peptides that overcome the effects of Bcl-2 may be clinically useful. We harnessed the death-promoting alpha helical properties of the BH3 domain of BAD by fusing it to the Antennapedia (ANT) domain, which allows for cell entry (ANTBH3BAD). Treatment of 32D cells with the ANTBH3BAD peptide results in a 99% inhibition of...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Identifiers

PMID: 11464217
DOI: 10.1038/sj.cdd.4400870

Genes

BAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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