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Article

Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site.

Oncogene - 13 Mar 2003

Do Tamara N, Rosal Ramon V, Drew Lisa, Raffo Anthony J, Michl Josef, Pincus Matthew R, Friedman Fred K, Petrylak Daniel P, Cassai Nicholas, Szmulewicz Joseph, Sidhu Gurdip, Fine Robert L, Brandt-Rauf Paul W

Abstract excerpt

p53 is the most frequently altered gene in human cancer and therefore represents an ideal target for cancer therapy. Several amino terminal p53-derived synthetic peptides were tested for their antiproliferative effects on breast cancer cell lines MDA-MB-468 (mutant p53), MCF-7 (overexpressed wild-type p53), and MDA-MB-157 (null p53). p53(15)Ant peptide representing the majority of the mouse double minute clone 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12629507
DOI: 10.1038/sj.onc.1206258

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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