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Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

5 Dec 2016

Abstract excerpt

Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by the retromer at the...

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PMID: 27917878
DOI: 10.1038/ncomms13476

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