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Article

Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.

BMJ (Clinical research ed.) - 11 Feb 2014

Metcalfe Kelly, Gershman Shelley, Ghadirian Parviz, Lynch Henry T, Snyder Carrie, Tung Nadine, Kim-Sing Charmaine, Eisen Andrea, Foulkes William D, Rosen Barry, Sun Ping, Narod Steven A

Abstract excerpt

OBJECTIVE: To compare the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast. DESIGN: Retrospective analysis. SETTING: 12 cancer genetics clinics. PARTICIPANTS: 390 women with a family history of stage I or II breast cancer who were carriers of BRCA1 and BRCA2 mutations and initially treated with unilateral or bilateral mastectomy. 181...

Topics

Adult
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Canada
DNA, Neoplasm
Female
Forecasting
Humans
Mastectomy
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Staging

Retrospective Studies

Survival Rate

United States

Source

Open in PubMed Open full text

Identifiers

PMID: 24519767
DOI: 10.1136/bmj.g226
PMCID: PMC3921438

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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