Article
Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets.
The American journal of pathology - 1 Jul 2002
Mueller Wolf, Hartmann Christian, Hoffmann Annegret, Lanksch Wolfgang, Kiwit Jürgen, Tonn Jörg, Veelken Julian, Schramm Johannes, Weller Michael, Wiestler Otmar D, Louis David N, von Deimling Andreas
Abstract excerpt
Oligoastrocytomas are heterogeneous tumors that have molecular features that overlap with either oligodendrogliomas or astrocytomas. Differences in the frequency of chromosomal losses of 1p and 19q in oligodendrogliomas are related to tumor location, with a low rate of allelic loss in tumors of the temporal and a high rate in tumors of the frontal, parietal, and occipital lobes. To test the possibility of...
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