Article
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2020
Bachvarova Velina, Dierker Tabea, Esko Jeffrey, Hoffmann Daniel, Kjellen Lena, Vortkamp Andrea
Abstract excerpt
Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones. Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes. To understand this difference, we have investigated...
Topics
- Animals
- Cell Proliferation
- Cells, Cultured
- Chondrocytes
- Chondroitin Sulfates
- Heparitin Sulfate
- Humans
- Mice
- Mice, Transgenic
- Mutation
- N-Acetylglucosaminyltransferases
- Phosphorylation
- Primary Cell Culture