Article
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase.
Genes & development - 15 Jun 1998
Bullock S L, Fletcher J M, Beddington R S, Wilson V A
Abstract excerpt
Heparan sulfate proteoglycans have been implicated in the presentation of a number of secreted signaling molecules to their signal-transducing receptors. We have characterized a gene trap mutation in the gene encoding a heparan sulfate biosynthetic enzyme, heparan sulfate 2-sulfotransferase (HS2S...
Topics
- Amino Acid Sequence
- Animals
- Biomarkers
- Bone and Bones
- Cell Line
- DNA Transposable Elements
- Embryo, Mammalian
- Embryonic and Fetal Development
- Eye
- Female
- Gene Expression
- Genes
- Homozygote
- In Situ Hybridization
- Kidney
- Male
- Mice
- Mice, Inbred C57BL