Article
Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice.
Endocrine journal - 1 Apr 2001
Yamada K, Ikegami H, Kawaguchi Y, Fujisawa T, Hotta M, Ueda H, Shintani M, Nojima K, Kawabata Y, Ono M, Nishino M, Itoi M, Babaya N, Shibata M, Makino S, Ogihara T
Abstract excerpt
Although type 1 and type 2 diabetes are regarded as clinically distinct diseases, several lines of evidence have suggested common genetic factors between the two types of diabetes. The non-obese diabetic (NOD) mouse, an animal model of type 1 diabetes, and the Nagoya-Shibata-Yasuda (NSY) mouse, a model of type 2 diabetes, are derived from the same outbred colony, Jcl:HCR, suggesting a shared susceptibility...
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