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Article

Molecular scanning of the gene for thioredoxin, an antioxidative and antiapoptotic protein, and genetic susceptibility to type 1 diabetes.

Annals of the New York Academy of Sciences - 1 Dec 2008

Ikegami Hiroshi, Ono Masaya, Fujisawa Tomomi, Hiromine Yoshihisa, Kawabata Yumiko, Yamato Eiji

Abstract excerpt

Oxidative stress has been implicated in the destruction of beta cells in type 1 diabetes (T1D). Thioredoxin has been shown to protect cells from oxidative stress and apoptosis. In this study, we screened for sequence variants of the human thioredoxin gene (TXN), and studied the association of the variants in persons with T1D in Japanese. The frequency of the A allele of the G/A SNP in the 3' flanking region was...

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Identifiers

PMID: 19120277
DOI: 10.1196/annals.1447.060

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TXN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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