Article
Somatic gene alteration of AIB1 gene in patients with breast cancer.
Endocrine journal - 1 Apr 2001
Shibata A, Hayashi Y, Imai T, Funahashi H, Nakao A, Seo H
Abstract excerpt
AIB1 (amplified in breast cancer 1) is a coactivator which stimulates the transcriptional activity of the liganded-estrogen receptor (ER). It has been reported that AIBI gene is amplified and overexpressed in some breast cancer cell lines. AIB1 contains a stretch of homopolymeric glutamines (poly-Q). We reported that the poly-Q shows polymorphism, which provides an opportunity to study somatic gene alteration...
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