Article
Association of single nucleotide polymorphisms of the interleukin-10 promoter gene and susceptibility to primary biliary cirrhosis: immunogenetic differences in Italian and Japanese patients.
Autoimmunity - 1 Dec 2002
Matsushita Masanao, Tanaka Atsushi, Kikuchi Kentaro, Kitazawa Eriko, Kawaguchi Naomi, Kawashima Yumi, Kato Takashi, Fujikawa Hirotoshi, Quaranta Stefano, Rosina Floriano, Gershwind M Eric, Miyakawa Hiroshi
Abstract excerpt
Several lines of data suggest that genetic factors play an important role in the onset and/or progression of primary biliary cirrhosis (PBC). Since PBC is an autoimmune disease, it is reasoned to assume that genes encoding cytokines may confer susceptibility to disease. Amongst these factors, interleukin-10 (IL-10) has received significant attention. The promoter region of IL-10 gene has three single nucleotide...
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