Article
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Nature - 5 Oct 2000
Irwin M, Marin M C, Phillips A C, Seelan R S, Smith D I, Liu W, Flores E R, Tsai K Y, Jacks T, Vousden K H, Kaelin W G
Abstract excerpt
The transcription factor E2F-1 induces both cell-cycle progression and, in certain settings, apoptosis. E2F-1 uses both p53-dependent and p53-independent pathways to kill cells. The p53-dependent pathway involves the induction by E2F-1 of the human tumour-suppressor protein p14ARF, which neutralizes HDM2 (human homologue of MDM2) and thereby stabilizes the p53 protein. Here we show that E2F-1 induces the...
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