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Article

P14ARF: The Absence that Makes the Difference.

Genes - 20 Jul 2020

Cilluffo Danilo, Barra Viviana, Di Leonardo Aldo

Abstract excerpt

P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14ARF functions can be played through interactions with several proteins. However, the majority of its activities are notoriously mediated by the p53 protein. Interestingly, recent studies suggest a new role...

Topics

Aneuploidy
Bridged Bicyclo Compounds, Heterocyclic
Cell Proliferation
HCT116 Cells
Humans
Phenotype
Sarcosine
Tumor Suppressor Protein p14ARF

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32698529
DOI: 10.3390/genes11070824
PMCID: PMC7397060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32698529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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