Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P14ARF: The Absence that Makes the Difference.

Genes - 20 Jul 2020

Cilluffo Danilo, Barra Viviana, Di Leonardo Aldo

Abstract excerpt

P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14ARF functions can be played through interactions with several proteins. However, the majority of its activities are notoriously mediated by the p53 protein. Interestingly, recent studies suggest a new role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Cell Proliferation
Share to Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Tumor Suppressor Protein p14ARF

Source

Open in PubMed Open full text

Identifiers

PMID: 32698529
DOI: 10.3390/genes11070824
PMCID: PMC7397060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P14ARF: The Absence that Makes the Difference.PMID 32698529Read ↗

Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathwaysSemantic proximity Read ↗

Dual Role of the Alternative Reading Frame ARF Protein in CancerSemantic proximity Read ↗

Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) TumorigenesisSemantic proximity Read ↗

Friends and foes: Our evolving understanding of the link between Fbxw7 and p53 in cancer.Semantic proximity Read ↗

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2Semantic proximity Read ↗

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblastsSemantic proximity Read ↗

p53 and E2f: partners in life and death.Semantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma.Semantic proximity Read ↗

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.Semantic proximity Read ↗

Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cellsSemantic proximity Read ↗

Unveiling a novel role for p19Arf (alternative reading frame) in mESC differentiation toward the pancreatic lineage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.