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Article

Genetic polymorphisms in cell cycle regulatory genes CCND1 and CDK4 are associated with susceptibility to breast cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000

Ullah Shah Abid, Mahjabeen Ishrat, Kayani Mahmood Akhtar

Abstract excerpt

PURPOSE: This study was performed to screen cyclin D1 (CCND1) and cyclin dependent kinases (CDK4) genes in order to evaluate their association with breast carcinogenesis. METHODS: The germline screening of these genes was carried out by combining polymerase chain reaction (PCR) and single-strand conformation polymorphism (SSCP), followed by DNA sequence analysis. A total of 400 individuals (200 breast cancer...

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Identifiers

PMID: 26416047

Genes

CCND1
CDK4

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