Article
Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentation.
Anticancer research - 1 Jan 2000
Wagner M, Klussmann J P, Fangmann R, Linder R, Elewa M E, Eidt S, Rose V M, Jungehulsing M, Schulze H J
Abstract excerpt
The cdknlA gene encodes CDKN1A, a protein that regulates cell cycle progression, terminal differentiation, and apoptosis. Polymorphisms or loss of heterozygosity of this usually biallelically expressed gene have no major impact on carcinogenesis. The prevalence of somatic mutations in malignancies is low. Gene rearrangements involving cdknlA are scarce. CDKN1A is expressed in both premalignant and malignant...
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