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Article

CDKN1C/p57kip2is a candidate tumor suppressor gene in human breast cancer

6 Mar 2008

Abstract excerpt

BACKGROUND: CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited. We hypothesized that decreased CDKN1C may be involved in human breast carcinogenesis in vivo. METHODS: We determined rates of allele...

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PMID: 18325103
DOI: 10.1186/1471-2407-8-68

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