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CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer

2 Oct 2013

Abstract excerpt

Inactivating mutations of the CDC73 tumor suppressor gene have been reported in parathyroid carcinomas (PC), in association with the loss of nuclear expression of the encoded protein, parafibromin. The aim of this study was to further investigate the role of the CDC73 gene in PC and evaluate whether gene carrier status and/or the loss of parafibromin staining might have an effect on the outcome of the disease. We...

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PMID: 24145611
DOI: 10.1530/ec-13-0046

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