Article
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.
Science (New York, N.Y.) - 13 Jul 2001
Lu Q, Lemke G
Abstract excerpt
Receptor tyrosine kinases and their ligands mediate cell-cell communication and interaction in many organ systems, but have not been known to act in this capacity in the mature immune system. We now provide genetic evidence that three closely related receptor tyrosine kinases, Tyro 3, Axl, and Mer, play an essential immunoregulatory role. Mutant mice that lack these receptors develop a severe lymphoproliferative...
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