Article
Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2001
Kawaguchi J, Azuma Y, Hoshi K, Kii I, Takeshita S, Ohta T, Ozawa H, Takeichi M, Chisaka O, Kudo A
Abstract excerpt
The migration and adhesion of osteoblasts requires several classical cadherins. Cadherin-11, one of the classical cadherins, was expressed in mouse osteoblasts in skull bone and femur, revealed by immunohistochemistry. To elucidate the function of cadherin-11 in osteoblastogenesis, cadherin-11 null mutant mice were investigated. Although apparently normal at birth, Alizarin red staining of null mutant mice showed...
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