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Article

In vivo impact of Dlx3 conditional inactivation in neural crest‐derived craniofacial bones

9 Aug 2012

Abstract excerpt

Mutations in DLX3 in humans lead to defects in craniofacial and appendicular bones, yet the in vivo activities related to Dlx3 function during normal skeletal development have not been fully elucidated. Here we used a conditional knockout approach to analyze the effects of neural crest deletion of Dlx3 on craniofacial bones development. At birth, mutant mice exhibit a normal overall positioning of the skull...

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PMID: 22886599
DOI: 10.1002/jcp.24175

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