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Article

Transforming Growth Factor-β Induces Osteoclast Ruffling and Chemotaxis: Potential Role in Osteoclast Recruitment

1 Jul 2001

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is released from the matrix during bone resorption and has been implicated in the pathogenesis of giant cell tumors of bone and the expansion of breast cancer metastases in bone. Because osteoclasts mediate tumor-induced osteolysis, we investigated whether TGF-beta stimulates osteoclast recruitment. Osteoclasts were isolated from rat long bones and time-lapse video...

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Identifiers

PMID: 11450699
DOI: 10.1359/jbmr.2001.16.7.1237

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