Molecular mechanisms of bone resorption

Abstract excerpt

This review focuses on osteoclast ontogeny and function, emphasizing three aspects. We describe how a combination of laboratory models available to study the cell plus examination of the osteopetroses, a family of sclerotic diseases of the skeleton, have yielded major insights into osteoclast ontogeny and function. We proceed to describe the cell and molecular machinery enabling osteoclasts to resorb bone. The...