Article
Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone.
Histopathology - 1 Sept 2011
Balla Peter, Moskovszky Linda, Sapi Zoltan, Forsyth Ramses, Knowles Helen, Athanasou Nick A, Szendroi Miklos, Kopper Laszlo, Rajnai Hajnalka, Pinter Ferenc, Petak Istvan, Benassi Maria Serena, Picci Piero, Conti Amalia, Krenacs Tibor
Abstract excerpt
AIMS: Epidermal growth factor receptor (EGFR) is implicated in bone remodelling. The aim was to determine whether EGFR protein expression contributes to the aggressiveness and recurrence potential of giant cell tumour of bone (GCTB), an osteolytic primary bone tumour that can exhibit markedly variable clinical behaviour. METHODS AND RESULTS: Immunohistochemical analysis on tissue microarrays (TMA) of 231 primary,...
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