Article
Role of the PI3K/AKT pathway in modulating cytoskeleton rearrangements and phenotype switching in rat pulmonary arterial vascular smooth muscle cells.
DNA and cell biology - 1 Jan 2014
Fan Zhiyu, Li Chunyu, Qin Chaoyi, Xie Liang, Wang Xiaoshuang, Gao Zhengxiang, Qiangbacuozhen, Wang Tao, Yu Li, Liu Hanmin
Abstract excerpt
Pulmonary arterial smooth muscle cell (PASMC) phenotype switching, which is characterized by changes in smooth muscle (SM)-specific gene expression, contributes to vascular remodeling in pulmonary hypertension. In addition, it has been shown that the transcription of SM-specific genes is modulate...
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