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Article

Enhancers of hypermutation.

Immunogenetics - 1 Jan 1996

Bachl J, Wabl M

Abstract excerpt

Hypermutation at the immunoglobulin (Ig) loci increases the mutation rate more than 10(5)-fold over the normal, spontaneous rate. We studied two kinds of cis-acting elements - 3' enhancers and promoters - in a system in which a gene encoding the mu heavy (H) chain (Igm) is transfected in vitro into a cell line with an active Ig mutator. A construct containing a rearranged Igm gene requires the 3' H enhancer for...

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Identifiers

PMID: 8881038
DOI: 10.1007/s002510050167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhancers of hypermutation.PMID 8881038Read ↗

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