Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants.

Molecular and cellular biology - 1 Aug 2001

Krause S A, Loupart M L, Vass S, Schoenfelder S, Harrison S, Heck M M

Abstract excerpt

Two alleles of the Drosophila melanogaster Rfc4 (DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome cohesion and condensation. These mutations produce larval phenotypes consistent with a role in DNA replication but also result in mitotic chromosomal defects appearing either as premature chromosome condensation-like or precocious sister...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Chromosome Disorders
Share to Chromosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indoles

Share to Mitosis

Share to Replication Protein C

Share to Salivary Glands

Source

Open in PubMed Open full text

Identifiers

PMID: 11438670
DOI: 10.1128/MCB.21.15.5156-5168.2001
PMCID: PMC87240

Genes

RFC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants.PMID 11438670Read ↗

Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants.Semantic proximity Read ↗

Orc mutants arrest in metaphase with abnormally condensed chromosomes.Semantic proximity Read ↗

Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund–Thomson syndromeSemantic proximity Read ↗

Mutational analysis of the Drosophila CMG helicase reveals relationships among chromosome integrity and the maintenance of spindle and centrosome structure.Semantic proximity Read ↗

Onset of the DNA replication checkpoint in the early Drosophila embryo.Semantic proximity Read ↗

CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells.Semantic proximity Read ↗

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.Semantic proximity Read ↗

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.Semantic proximity Read ↗

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.Semantic proximity Read ↗

Loss of Drosophila Myb interrupts the progression of chromosome condensation.Semantic proximity Read ↗

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.Semantic proximity Read ↗

Drosophila chk2 plays an important role in a mitotic checkpoint in syncytial embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.