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Article

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.

Molecular and cellular biology - 1 Sept 1998

Shimomura T, Ando S, Matsumoto K, Sugimoto K

Abstract excerpt

The RFC5 gene encodes a small subunit of replication factor C (RFC) complex in Saccharomyces cerevisiae and has been shown to be required for the checkpoints which respond to replication block and DNA damage. Here we describe the isolation of RAD24, known to play a role in the DNA damage checkpoint, as a dosage-dependent suppressor of rfc5-1. RAD24 overexpression suppresses the sensitivity of rfc5-1 cells to...

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Source

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Identifiers

PMID: 9710632
DOI: 10.1128/MCB.18.9.5485
PMCID: PMC109133

Genes

RFC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.PMID 9710632Read ↗

Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.Semantic proximity Read ↗

Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.Semantic proximity Read ↗

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.Semantic proximity Read ↗

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Semantic proximity Read ↗

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.Semantic proximity Read ↗

Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1.Semantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing.Semantic proximity Read ↗

Functional connection between the Clb5 cyclin, the protein kinase C pathway and the Swi4 transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

The ELG1 clamp loader plays a role in sister chromatid cohesion.Semantic proximity Read ↗

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