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Article

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.

Molecular and cellular biology - 1 Aug 2001

Fan S, Ma Y X, Gao M, Yuan R Q, Meng Q, Goldberg I D, Rosen E M

Abstract excerpt

Hepatocyte growth factor (scatter factor) (HGF/SF) is a pleiotrophic mediator of epithelial cell motility, morphogenesis, angiogenesis, and tumorigenesis. HGF/SF protects cells against DNA damage by a pathway from its receptor c-Met to phosphatidylinositol 3-kinase (PI3K) to c-Akt, resulting in enhanced DNA repair and decreased apoptosis. We now show that protection against the DNA-damaging agent adriamycin (ADR;...

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Identifiers

PMID: 11438654
DOI: 10.1128/MCB.21.15.4968-4984.2001
PMCID: PMC87224

Genes

HGF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.PMID 11438654Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor induced endothelial progenitor cell proliferation and migrationSemantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.Semantic proximity Read ↗

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.Semantic proximity Read ↗

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Semantic proximity Read ↗

The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.Semantic proximity Read ↗

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.Semantic proximity Read ↗

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.Semantic proximity Read ↗

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