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Article

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.

Oncogene - 16 Mar 2000

Gual P, Giordano S, Williams T A, Rocchi S, Van Obberghen E, Comoglio P M

Abstract excerpt

A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Binder-1 (Gab1). Gab1 is also phosphorylated in response to Epidermal Growth Factor (EGF) but is...

Read the complete abstract on PubMed

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Share to Epidermal Growth Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 10734310
DOI: 10.1038/sj.onc.1203514

Genes

HGF
EGF
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.PMID 10734310Read ↗

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