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Article

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.

Oncogene - 13 Mar 2003

Yamasaki Satoru, Nishida Keigo, Yoshida Yuichi, Itoh Motoyuki, Hibi Masahiko, Hirano Toshio

Abstract excerpt

Grb2-associated binder-1 (Gab1) is a pleckstrin homology (PH) domain-containing adapter molecule that is believed to function downstream of receptors for growth factors and cytokines. We previously found that deficiency in the mouse Gab1 gene led to embryonic lethality and defects in ERK activation in response to growth factors and cytokines. Here, we established immortalized Gab1-/- cell lines and analysed roles...

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Identifiers

PMID: 12629518
DOI: 10.1038/sj.onc.1206284

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.PMID 12629518Read ↗

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.Semantic proximity Read ↗

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.Semantic proximity Read ↗

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.Semantic proximity Read ↗

A role for the scaffolding adapter GAB2 in breast cancer.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.Semantic proximity Read ↗

G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.Semantic proximity Read ↗

Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Semantic proximity Read ↗

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