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Article

Perforin-dependent neurologic injury in a viral model of multiple sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 1998

Murray P D, McGavern D B, Lin X, Njenga M K, Leibowitz J, Pease L R, Rodriguez M

Abstract excerpt

In this study we demonstrate perforin-mediated cytotoxic effector function is necessary for viral clearance and may directly contribute to the development of neurologic deficits after demyelination in the Theiler's murine encephalomyelitis virus (TMEV) model of multiple sclerosis. We previously demonstrated major histocompatability complex (MHC) class I-deficient (beta2m-deficient) mice with an otherwise...

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Identifiers

PMID: 9736651
PMCID: PMC6793251

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