Article
Perforin-dependent neurologic injury in a viral model of multiple sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 1998
Murray P D, McGavern D B, Lin X, Njenga M K, Leibowitz J, Pease L R, Rodriguez M
Abstract excerpt
In this study we demonstrate perforin-mediated cytotoxic effector function is necessary for viral clearance and may directly contribute to the development of neurologic deficits after demyelination in the Theiler's murine encephalomyelitis virus (TMEV) model of multiple sclerosis. We previously d...
Topics
- Animals
- Chronic Disease
- Demyelinating Diseases
- Disease Models, Animal
- Exocytosis
- Fas Ligand Protein
- Female
- Histocompatibility Antigens Class I
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Microscopy, Electron
- Multiple Sclerosis
- Mutation
- Neurons
- Perforin