Article
Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2020
Stephenson Alexandra, Eszlinger Markus, Stewardson Paul, McIntyre John B, Boesenberg Eileen, Bircan Rifat, Sancak Seda, Gozu Hulya I, Ghaznavi Sana, Krohn Knut, Paschke Ralf
Abstract excerpt
Background: Constitutively activating mutations in the thyrotropin receptor (TSHR) and the guanine nucleotide-binding protein G subunit alpha (GNAS) are the primary cause of hot thyroid nodules (HTNs). The reported prevalence of TSHR and GNAS mutations in HTNs varies. Previous studies show TSHR mutations in 8-82% of HTNs and GNAS mutations in 8-75% of HTNs. With sensitive and comprehensive targeted...
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