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Article

The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement.

Pharmacogenetics - 1 Jun 2001

van der Weide J, Steijns L S, van Weelden M J, de Haan K

Abstract excerpt

The cytochrome P450 enzyme CYP2C9 catalyses the metabolism of numerous therapeutic agents, including the anti-epileptic drug phenytoin. CYP2C9 is genetically polymorphic: two allelic variants are known, CYP2C9*2 and CYP2C9*3, differing from the wild-type CYP2C9*1 by a single point mutation. Both mutant alleles are associated with markedly impaired metabolic capacity for many CYP2C9 substrates compared to the...

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Identifiers

PMID: 11434505
DOI: 10.1097/00008571-200106000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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