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Article

Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients.

Pharmacogenomics - 1 Sept 2012

Hung Chin-Chuan, Huang Hsiao-Ching, Gao Yun-Han, Chang Wei-Lun, Ho Jia-Ling, Chiou Mu-Han, Hsieh Yow-Wen, Liou Horng-Huei

Abstract excerpt

AIM: The present study aimed to investigate the associations between variants in pharmacokinetic- and pharmacodynamic-related genes with the dosages, concentrations and concentration-dose ratios (CDRs) of phenytoin (PHT). METHODS & RESULTS: Eleven genetic polymorphisms in the six candidate genes were detected in 269 epileptic patients under maintenance PHT monotherapy by real-time PCR and PCR-RFLP. Results of a...

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Identifiers

PMID: 22966884
DOI: 10.2217/pgs.12.117

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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